Table of Contents
Summary
This trial is comparing the effects and safety in treating men with prostate cancer between
irreversible electroporation and radical prostatectomy.
Description
Four hundred and thirty-eight patients with localized prostate cancer will include in this
study. The clinical trial validation process will be as follows: (1) all patients are
randomly divided into two arms: arm 1, irreversible electroporation; group 2, radical
prostatectomy. The primary outcome is the 5-year free tumor progression rate.
Study Design
Conditions
Prostate Cancer
Intervention
Focal therapy(Irreversible Electroporation), Radical prostatectomy
Location
Shanghai East Hospital, Tongji University School of Medicine
Shanghai
Shanghai
China
200120
Status
Not yet recruiting
Source
Shanghai East Hospital
Results (where available)
Links
Published on BioPortfolio: 2020-02-20T18:46:15-0500
Medical and Biotech [MESH] Definitions
Prostate-specific Antigen
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Prostatectomy
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
Neoadjuvant Therapy
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Fenretinide
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Ultrasound, High-intensity Focused, Transrectal
Tissue ablation of the PROSTATE performed by ultrasound from a transducer placed in the RECTUM. The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA).
