The World Health Organisation (WHO) has recommended a combination of Baricitinib, an arthritic drug, and corticosteroids for the treatment of patients with severe or critical COVID-19.

In a statement on Thursday, the global health body said the recommendation is based on new evidence from seven trials involving over 4,000 patients with severe, non-severe, and critical COVID-19 infections.

According to the experts, the recommendation was based on moderate certainty evidence that it improves survival and reduces the need for ventilation; and shows no observed increase in adverse effects.

The experts said that Baricitinib had similar effects like other arthritis drugs called interleukin-6 (IL-6) inhibitors, so when both are available, they suggested choosing one based on cost, availability, and clinician experience.

The experts said it was not recommended to use both drugs at the same time. However, the experts advised against the use of ruxolitinib and tofacitinib, two other JAK inhibitors, for patients with severe or critical COVID-19.

“The WHO experts note that baricitinib has similar effects to other arthritis drugs called interleukin-6 (IL-6) inhibitors so, when both are available, they suggest choosing one based on cost, availability, and clinician experience. It is not recommended to use both drugs at the same time,” the statement reads.

The WHO made a “conditional recommendation” for the use of sotrovimab, a monoclonal antibody (made by cloning a unique white blood cell), in patients with non-severe COVID-19, but only in those at highest risk of hospitalisation.

“A similar recommendation has been made by WHO for another monoclonal antibody drug (casirivimab-imdevimab),” the statement added.

“The experts also note that there were insufficient data to recommend one monoclonal antibody treatment over another – and they acknowledge that their effectiveness against new variants like omicron is still uncertain.

“As such, they say guidelines for monoclonal antibodies will be updated when additional data become available.”

 



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