Covid19

“The recent increase in Covid-19 cases has caused a substantial rise in the utilization of monoclonal antibody drugs, particularly in areas of the country with low vaccination rates,” Dr. Daniel Skovronsky, Lilly’s chief scientific and medical officer and president of Lilly Research Laboratories, said in a statement. “Lilly developed bamlanivimab and etesevimab for administration together, […]

Abstract The COVID-19 pandemic remains uncontrolled despite the rapid rollout of safe and effective SARS-CoV-2 vaccines, underscoring the need to develop highly effective antivirals. In the setting of waning immunity from infection and vaccination, breakthrough infections are becoming increasingly common and treatment options remain limited. Additionally, the emergence of SARS-CoV-2 variants of concern with their […]

Introduction: Need of an antiviral against Covid-19 prompted clinical trials all over the world and based on initial promising trends, remdesivir was widely used all over the world, including India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. Methods: This is a record-based […]

Convalescent plasma, IVIG, and remdesivir have successfully helped immunocompromised patients recover from the virus. The results of a new study published in The International Journal of Molecular Sciences shows that convalescent plasma, IVIG, and remdesivir help immunocompromised patients recover from COVID-19 without B-cell population recovery. Remdesivir inhibits the replication of the virus, while convalescent plasma […]

A drug created by a Texas A&M University professor could be the most effective treatment yet of patients with COVID-19, including the aggressive variants of the virus such as Delta and others. The drug compound, called MPI8, has stopped the replication of the virus in laboratory tests. It was created by a Texas A&M research […]

Abstract A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy, the potential to increase the therapeutic index of drugs and the potential to reduce the emergence of drug resistance. Here, […]

A panel set up to look into grievances against Gautam Budh Nagar private hospitals during the second wave of Covid-19 on Thursday ordered the district chief medical officer (CMO) to act against Prayag Hospital in Sector 41 for administering 11 vials of remdesivir to a woman in violation of protocol. The patient later died. The […]

Private hospitals have asked the State Government to focus more on micro-containment zones so that coronavirus spread is curbed and normal activities can be resumed outside the containment zones. Currently, there are fewer than 100 micro containment zones in the city. The BBMP had some time back reclassified the micro containment zones as places with […]

The resurgence of COVID-19 because of the Delta variant has led to significant imbalances in the supply and demand of commonly used medications for hospitalized patients, including tocilizumab, dexamethasone, baricitinib, and remdesivir. According to a report from Vizient, the average demand for these medications has dramatically increased over recent months, whereas fill rates for hospital […]

WEST PALM BEACH, Fla. — It’s not a one-size-fits-all situation, but local hospitals have developed standard protocols for treating COVID-19. The medicines you receive at the hospital if you are admitted with COVID-19 symptoms depends on many factors. It also depends on what hospital you go to. SPECIAL COVERAGE: Coronavirus Four infectious disease specialists affiliated […]

Photo by Micromedia Publications OCEAN COUNTY – RWJBarnabas Health is now offering a third COVID-19 dose for those who are immunocompromised.    The Centers for Disease Control and Prevention (CDC) has recommended that people whose immune systems are moderately to severely compromised should receive a third dose of the mRNA COVID-19 vaccine (Pfizer or Moderna) after […]

Clinical MedicineIn-Press PreviewVirology Free access | 10.1172/JCI151697 Ravindra Ganesh,1 Colin F. Pawlowski,2 John C. O’Horo,3 Lori L. Arndt,4 Richard F. Arndt,5 Sarah Bell,6 Dennis M. Bierle,1 Molly Destro Borgen,7 Sara Hanson,8 Alexander Heyliger,9 Jennifer L. Larsen,6 Patrick J. Lenehan,10 Robert Orenstein,11 Arjun Puranik,2 Leigh L. Speicher,12 Sidna M. Tulledge-Scheitel,13 AJ Venkatakrishnan,2 Caroline G. Wilker,14 Andrew […]

An oral version of remdesivir is being developed by scientists at the University of California, San Diego (UCSD) to combat the SARS-CoV-2 virus early in its infection cycle. Though still in preclinical trials, results suggest it could reduce disease severity and hospitalizations thanks to its longer half-life, greater efficacy and reduced toxicity when compared to […]

MONTGOMERY, Ala. (WSFA) – Monoclonal antibody infusions have been used for months in Montgomery, but with COVID-19 case numbers growing, there’s a renewed push for the treatment to prevent further crowding of the city’s hospitals. At a press conference last week, State Health Officer Scott Harris was asked about the best treatment available for people […]

Scientists at University of California, San Diego, have developed a way to put remdesivir and other intravenous COVID-19 treatments into a capsule that patients could safely take orally at home, according to a paper in an online issue of Antimicrobial Agents and Chemotherapy. Since the pandemic began, scientists worldwide have been seeking a treatment that […]

The Food and Drug Administration (FDA) has authorized the use of REGEN-COV (casirivimab and imdevimab) for postexposure prophylaxis of COVID-19 in individuals (12 years of age and older weighing at least 40kg) who are at high risk for progression to severe COVID-19, including hospitalization or death. The investigational agent was previously granted Emergency Use Authorization […]